Goal-directed and habitual control in the basal ganglia: implications for Parkinson's disease
Identifieur interne : 000053 ( France/Analysis ); précédent : 000052; suivant : 000054Goal-directed and habitual control in the basal ganglia: implications for Parkinson's disease
Auteurs : Peter Redgrave [Royaume-Uni] ; Manuel Rodriguez [Espagne] ; Yoland Smith [États-Unis] ; Maria C. Rodriguez-Oroz [Espagne] ; Stephane Lehericy [France] ; Hagai Bergman [Israël] ; Yves Agid [France] ; Mahlon R. Delong [États-Unis] ; Jose A. Obeso [Espagne]Source :
- Nature Reviews Neuroscience [ 1471-003X ] ; 2010-11.
Abstract
Progressive loss of the ascending dopaminergic projection in the basal ganglia is a fundamental pathological feature of Parkinson's disease. Studies in animals and humans have identified spatially segregated functional territories in the basal ganglia for the control of goal-directed and habitual actions. In patients with Parkinson's disease the loss of dopamine is predominantly in the posterior putamen, a region of the basal ganglia associated with the control of habitual behaviour. These patients may therefore be forced into a progressive reliance on the goal-directed mode of action control that is mediated by comparatively preserved processing in the rostromedial striatum. Thus, many of their behavioural difficulties may reflect a loss of normal automatic control owing to distorting output signals from habitual control circuits, which impede the expression of goal-directed action.
Url:
DOI: 10.1038/nrn2915
Affiliations:
- Espagne, France, Israël, Royaume-Uni, États-Unis
- Canaries, Communauté de Madrid, Communauté forale de Navarre, Île-de-France
- Paris
- Hôpital de la Salpêtrière, Université Pierre-et-Marie-Curie
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All Rights Reserved.</publisher><date type="published" when="2010-11">2010-11</date><biblScope unit="volume">11</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="760">760</biblScope><biblScope unit="page" to="772">772</biblScope></imprint><idno type="ISSN">1471-003X</idno></series><idno type="istex">3BA9A202EF14D74559FB13E24057FEEE3DAE709F</idno><idno type="DOI">10.1038/nrn2915</idno><idno type="ArticleID">nrn2915</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1471-003X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">Progressive loss of the ascending dopaminergic projection in the basal ganglia is a fundamental pathological feature of Parkinson's disease. Studies in animals and humans have identified spatially segregated functional territories in the basal ganglia for the control of goal-directed and habitual actions. In patients with Parkinson's disease the loss of dopamine is predominantly in the posterior putamen, a region of the basal ganglia associated with the control of habitual behaviour. These patients may therefore be forced into a progressive reliance on the goal-directed mode of action control that is mediated by comparatively preserved processing in the rostromedial striatum. Thus, many of their behavioural difficulties may reflect a loss of normal automatic control owing to distorting output signals from habitual control circuits, which impede the expression of goal-directed action.</div></front></TEI><affiliations><list><country><li>Espagne</li><li>France</li><li>Israël</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Canaries</li><li>Communauté de Madrid</li><li>Communauté forale de Navarre</li><li>Île-de-France</li></region><settlement><li>Paris</li></settlement><orgName><li>Hôpital de la Salpêtrière</li><li>Université Pierre-et-Marie-Curie</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Redgrave, Peter" sort="Redgrave, Peter" uniqKey="Redgrave P" first="Peter" last="Redgrave">Peter Redgrave</name></noRegion><name sortKey="Redgrave, Peter" sort="Redgrave, Peter" uniqKey="Redgrave P" first="Peter" last="Redgrave">Peter Redgrave</name></country><country name="Espagne"><region name="Canaries"><name sortKey="Rodriguez, Manuel" sort="Rodriguez, Manuel" uniqKey="Rodriguez M" first="Manuel" last="Rodriguez">Manuel Rodriguez</name></region><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. 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